Does opting out from one number affect messages from other numbers in a 10DLC campaign?

Yes, in the US 10DLC system, opting out from one Plivo number within a campaign will opt the user out from ALL numbers associated with that campaign. For instance, if a customer opts out of Number A under Campaign X, they will also be opted out of Numbers B, C, and D linked to that campaign. This is designed to protect consumers from unwanted messages.