Yes you can disconnect a specific call by using the below mentioned API  


DELETE https://api.plivo.com/v1/Account/{auth_id}/Call/{call_uuid}/ 



Note: If CallUUID is not specified, all live calls in that particular account will get disconnected.


Please refer the below mentioned link on how to disconnect a specific call https://www.plivo.com/docs/getting-started/hang-up-calls/