Yes, you can make an outbound call to the SIP URI of a Plivo application. For example, you can make an HTTP POST request to originate an outbound call to “” which is the SIP URL used to identify the Plivo application.

Having said that, if you’re expecting to receive calls delivered to your SIP URI, you would create a SIP endpoint that’s attached to your Plivo application in the ‘Endpoint’ tab and share them with others, not the SIP URL of your application.